Medisinen ble opprinnelig utviklet i Frankrike til bruk i det franske forsvaret. Den skulle brukes av det franske flyvåpenets soldater, slik at de skulle fileøle mindre tretthet og klare å konsentrere seg bedre om oppgavene sine.

Edgar and Seidel (1997) investigated the effects of modafinil on sleep-wake EEG and locomotor activity in Stay rats compared with the results of methamphetamine. They identified that modafinil elevated locomotor exercise only a little bit contrary to methamphetamine which induced profound improves in locomotor activity.

Modafinil has continually been shown to proficiently stop extra daytime sleepiness without the need of disrupting ordinary nighttime slumber, that makes it an extremely important cure for those with narcolepsy‍[seven] or related sleep Conditions such as obstructive snooze apnea.‍[8]

No considerable alterations in system bodyweight are noticed in scientific trials, Even though reduced hunger and weight reduction are actually famous in young children and adolescents.

C: Use with caution if Positive aspects outweigh challenges. Animal reports show chance and human scientific studies not obtainable or neither animal nor human research performed.

No withdrawal signs or symptoms have been observed in individuals with modafinil procedure cessation for the duration of 14 days of observation, but in individuals with narcolepsy, sleepiness returned. 

triclabendazole will increase the stage or influence of modafinil by affecting hepatic enzyme CYP2C19 metabolism.

Sebban et al printed 2 research in 1999 using eletroen-cephalography in Dwell rats to check modafinil at the side of the general dopamine receptor antagonist clozapine or perhaps the selective D2 antagonist raclopride. They identified that modafinil bolstered the EEG synchronization attributable to raclopride, and it had been ready to attenuate in both equally cortices the synchronizing effects of clozapine, that has an α1 adrenergic receptor antagonist Qualities.

Moreover, Cephalon entered agreements with several generic drug brands to delay the sale of generic modafinil from the US.

nefazodone will increase the stage or effect of modafinil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.

apalutamide will reduce the level or influence of modafinil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Stay away from or Use Alternate Drug. Coadministration of apalutamide, a robust CYP3A4 inducer, with drugs which can be CYP3A4 substrates may lead to lower publicity to those prescription drugs.

They found that anterior cingulate get more info activation increased in the majority of subjects, and working memory enhanced inside a minority of topics, but no subjects with reduced anterior cingulated activation shown improved Doing the job memory. A submit-hoc analysis of the information also confirmed that those that enhanced on modafinil experienced small baseline scores. These benefits indicated into the authors that low dose modafinil could have an anterior cingulate cortex mediated impact on Doing the job memory in impaired schizophrenics with specific features.

stiripentol will raise the level or effect of modafinil by influencing hepatic enzyme CYP2C19 metabolism. Modify Therapy/Keep an eye on Closely. Think about lessening the dose of CYP2C19 substrates, if adverse reactions are expert when administered concomitantly with stiripentol.

Narcolepsy: First-line treatment; Modafinil is utilized to treat the daytime fatigue connected with narcolepsy, and it hasn't been demonstrated to boost signs or symptoms of cataplexy.